The Zebrafish Model

 

 

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Zebrafish are at the forefront of neurobiological research and have been gaining popularity as a viable and valid behavioral model in a variety of research applications (e.g., assessing drug induced behavioral changes). This model becomes even more attractive when considering the behavioral changes that follow exposure to water-soluble compounds although compounds can be administered by injection.

 

The field of zebrafish research has a firm foundation in the realm of genetics and developmental biology. The volume of research in this area, coupled with concerted efforts at replication and validation of the findings have effectively established the zebrafish model as an important one within these fields.

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A host of studies have expanded the utility of the zebrafish model into the fields of neuroscience, cognition, and behavior (broadly defined). With the recent sequencing of the genome, along with the ease and availability of genetic mutant models, the opportunity exists to expand upon the knowledge of the genetic origins and the influencing factors of genes on neurobehavioral components, most notably, learning and memory.

Biochemical, histological, neurological, and anatomical data suggest that zebrafish are a viable model of human disease states and a solid candidate for the screening of pharmacotherapies (see Lamb, Echevarria & Jouandot 2012; or Collier & Echevarria 2013 for more information).